Angiotensin-Converting Enzyme 2: SARS-CoV-2 Receptor and Regulator of the Renin-Angiotensin System

Gheblawi, Mahmoud; Wang, Kaiming; Viveiros, Anissa; Nguyen, Quynh; Zhong, Jiu-Chang; J. Turner, Anthony; K. Raizada, Mohan; B. Grant, Maria; Y. Oudit, Gavin

doi:10.1161/circresaha.120.317015

Public

Angiotensin-Converting Enzyme 2: SARS-CoV-2 Receptor and Regulator of the Renin-Angiotensin System

Published in Circulation Research • Apr 8, 2020

Authors:

Mahmoud Gheblawi

Kaiming Wang

Anissa Viveiros

Abstract

ACE2 (angiotensin-converting enzyme 2) has a multiplicity of physiological roles that revolve around its trivalent function: a negative regulator of the renin-angiotensin system, facilitator of amino acid transport, and the severe acute respiratory syndrome-coronavirus (SARS-CoV) and SARS-CoV-2 rece...

Subject

Angiotensin-converting enzyme 2

Renin–angiotensin system

Receptor

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