Infant High-Grade Gliomas Comprise Multiple Subgroups Characterized by Novel Targetable Gene Fusions and Favorable Outcomes

Clarke, Matthew; Mackay, Alan; Ismer, Britta; C. Pickles, Jessica; G. Tatevossian, Ruth; Newman, Scott; A. Bale, Tejus; Stoler, Iris; Izquierdo, Elisa; Temelso, Sara; M. Carvalho, Diana; Molinari, Valeria; Burford, Anna; Howell, Louise; Virasami, Alex; R. Fairchild, Amy; Avery, Aimee; Chalker, Jane; Kristiansen, Mark; Haupfear, Kelly; D. Dalton, James; Orisme, Wilda; Wen, Ji; Hubank, Michael; M. Kurian, Kathreena; Rowe, Catherine; Maybury, Mellissa; Crosier, Stephen; Knipstein, Jeffrey; Schüller, Ulrich; Kordes, Uwe; E. Kram, David; Snuderl, Matija; Bridges, Leslie; J. Martin, Andrew; J. Doey, Lawrence; Al-Sarraj, Safa; Chandler, Christopher; Zebian, Bassel; Cairns, Claire; Natrajan, Rachael; K.R. Boult, Jessica; P. Robinson, Simon; Sill, Martin; J. Dunkel, Ira; W. Gilheeney, Stephen; K. Rosenblum, Marc; Hughes, Debbie; Z. Proszek, Paula; J. Macdonald, Tobey; Preusser, Matthias; Haberler, Christine; Slavc, Irene; Packer, Roger; Ng, Ho-Keung; Caspi, Shani; Popović, Mara; Faganel Kotnik, Barbara; D. Wood, Matthew; Baird, Lissa; Ashok Davare, Monika; A. Solomon, David; Kristin Olsen, Thale; Brandal, Petter; Farrell, Michael; B. Cryan, Jane; Capra, Michael; Karremann, Michael; Schittenhelm, Jens; U. Schuhmann, Martin; Ebinger, Martin; N.M. Dinjens, Winand; Kerl, Kornelius; Hettmer, Simone; Pietsch, Torsten; Andreiuolo, Felipe; Hernáiz Driever, Pablo; Korshunov, Andrey; Hiddingh, Lotte; C. Worst, Barbara; Sturm, Dominik; Zuckermann, Marc; Witt, Olaf; Bloom, Tabitha; Mitchell, Clare; Miele, Evelina; Stefania Colafati, Giovanna; Diomedi-Camassei, Francesca; Bailey, Simon; S. Moore, Andrew; E.G. Hassall, Timothy; P. Lowis, Stephen; Tsoli, Maria; J. Cowley, Mark; S. Ziegler, David; A. Karajannis, Matthias; Aquilina, Kristian; R. Hargrave, Darren; Carceller, Fernando; V. Marshall, Lynley; von Deimling, Andreas; M. Kramm, Christof; M. Pfister, Stefan; Sahm, Felix; J. Baker, Suzanne; Mastronuzzi, Angela; Carai, Andrea; Vinci, Maria; Capper, David; Popov, Sergey; W. Ellison, David; S. Jacques, Thomas; T.W. Jones, David; Jones, Chris

doi:10.1158/2159-8290.cd-19-1030

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Infant High-Grade Gliomas Comprise Multiple Subgroups Characterized by Novel Targetable Gene Fusions and Favorable Outcomes

Shared by NobleBlocks on Jul 1, 2020 • 12:00 AM UTC

Authors:

Matthew Clarke

Alan Mackay

Britta Ismer

Abstract

Abstract Infant high-grade gliomas appear clinically distinct from their counterparts in older children, indicating that histopathologic grading may not accurately reflect the biology of these tumors. We have collected 241 cases under 4 years of age, and carried out histologic review, methylation pr...

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