Cysteine depletion induces pancreatic tumor ferroptosis in mice

A. Badgley, Michael; M. Kremer, Daniel; Carlo Maurer, H.; E. DelGiorno, Kathleen; Lee, Ho‐Joon; Purohit, Vinee; R. Sagalovskiy, Irina; Ma, Alice; Kapilian, Jonathan; E. M. Firl, Christina; R. Decker-Farrell, Amanda; A. Sastra, Steve; F. Palermo, Carmine; R. Andrade, Leonardo; Sajjakulnukit, Peter; Zhang, Li; P. Tolstyka, Zachary; Hirschhorn, Tal; Lamb, Candice; Liu, Tong; Gu, Wei; Scott Seeley, E.; Stone, Everett; Georgiou, George; Manor, Uri; C. Iuga, Alina; M. Wahl, Geoffrey; R. Stockwell, Brent; A. Lyssiotis, Costas; P. Olive, Kenneth

doi:10.1126/science.aaw9872

Public

Cysteine depletion induces pancreatic tumor ferroptosis in mice

Published in Science • Apr 2, 2020

Authors:

Michael A. Badgley

Daniel M. Kremer

H. Carlo Maurer

Abstract

Ferroptotic cell death and cancer Cell death can occur through different mechanisms, several of which are being explored as potential targets for cancer treatment. One form of cell death that has attracted recent interest is ferroptosis, which is triggered by high intracellular levels of lipid react...

Subject

Cysteine

Cancer research

Chemistry

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