Phase 1 study of MRX34, a liposomal miR-34a mimic, in patients with advanced solid tumours

S. Hong, David; Kang, Yoon‐Koo; J. Borad, Mitesh; C. Sachdev, Jasgit; Ejadi, Samuel; Yeong Lim, Ho; Brenner, Andrew; Park, Keunchil; Lee, Jae‐Lyun; Kim, Tae‐You; Shin, SangJoon; Becerra, Carlos; S. Falchook, Gerald; Stoudemire, Jay; Martin, Desiree; Kelnar, Kevin; J. Peltier, Heidi; Bonato, Vinícius; G. Bader, Andreas; Smith, Susan; Kim, Sinil; O’Neill, Vincent; Shaalan Beg, Muhammad

doi:10.1038/s41416-020-0802-1

Public

Phase 1 study of MRX34, a liposomal miR-34a mimic, in patients with advanced solid tumours

Published in British Journal of Cancer • Apr 1, 2020

Authors:

David S. Hong

Yoon‐Koo Kang

Mitesh J. Borad

Abstract

BACKGROUND: In this first-in-human, Phase 1 study of a microRNA-based cancer therapy, the recommended Phase 2 dose (RP2D) of MRX34, a liposomal mimic of microRNA-34a (miR-34a), was determined and evaluated in patients with advanced solid tumours. METHODS: Adults with various solid tumours refractory...

Subject

Medicine

Chills

Adverse effect

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!