Comparative Replication and Immune Activation Profiles of SARS-CoV-2 and SARS-CoV in Human Lungs: An Ex Vivo Study With Implications for the Pathogenesis of COVID-19

Chu, Hin; Fuk‐Woo Chan, Jasper; Wang, Yixin; Tsz‐Tai Yuen, Terrence; Chai, Yue; Hou, Yuxin; Shuai, Huiping; Yang, Dong; Hu, Bingjie; Huang, Xiner; Zhang, Xi; Cai, Jian‐Piao; Zhou, Jie; Yuan, Shuofeng; Kok, Kin‐Hang; Kai‐Wang To, Kelvin; Hau-Yee Chan, Ivy; Zhang, Jinxia; Sit, Ko‐Yung; Au, Wing‐Kuk; Yuen, Kwok‐Yung

doi:10.1093/cid/ciaa410

Public

Comparative Replication and Immune Activation Profiles of SARS-CoV-2 and SARS-CoV in Human Lungs: An Ex Vivo Study With Implications for the Pathogenesis of COVID-19

Published in Clinical Infectious Diseases • Apr 8, 2020

Authors:

Hin Chu

Jasper Fuk‐Woo Chan

Yixin Wang

Abstract

BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an emerging coronavirus that has resulted in more than 2 000 000 laboratory-confirmed cases including over 145 000 deaths. Although SARS-CoV-2 and SARS-CoV share a number of common clinical manifestations, SARS-CoV-2 appears...

Subject

Tissue tropism

Tropism

Virology

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