Multiple links between 5-methylcytosine content of mRNA and translation

Schümann, Ulrike; Zhang, Hena; Sibbritt, Tennille; Pan, Anyu; Horváth, Attila; Gross, Simon; J. Clark, Susan; Yang, Li; Preiß, Thomas

doi:10.1186/s12915-020-00769-5

Public

Multiple links between 5-methylcytosine content of mRNA and translation

Published in BMC Biology • Apr 15, 2020

Authors:

Ulrike Schümann

Hena Zhang

Tennille Sibbritt

Abstract

Abstract Background 5-Methylcytosine (m 5 C) is a prevalent base modification in tRNA and rRNA but it also occurs more broadly in the transcriptome, including in mRNA, where it serves incompletely understood molecular functions. In pursuit of potential links of m 5 C with mRNA translation, we perfor...

Subject

Biology

Polysome

Transcriptome

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