MSC-induced lncRNA HCP5 drove fatty acid oxidation through miR-3619-5p/AMPK/PGC1α/CEBPB axis to promote stemness and chemo-resistance of gastric cancer

Wu, Honglei; Liu, Bin; Chen, Zhaosheng; Li, Guangchun; Zhang, Zhen

doi:10.1038/s41419-020-2426-z

Public

MSC-induced lncRNA HCP5 drove fatty acid oxidation through miR-3619-5p/AMPK/PGC1α/CEBPB axis to promote stemness and chemo-resistance of gastric cancer

Shared by NobleBlocks on Apr 16, 2020 • 12:00 AM UTC

Authors:

Honglei Wu

Bin Liu

Zhaosheng Chen

Abstract

Abstract Chemotherapy is the first-tier treatment regime for gastric cancer (GC) patients at advance stages. Mesenchymal stem cell (MSC) cam affect drug-resistance of GC cells in tumor microenvironment, but the detailed mechanism remains poorly understood. Present study aimed to investigate the regu...

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