Pitfalls in assessing stromal tumor infiltrating lymphocytes (sTILs) in breast cancer

Kos, Zuzana; Roblin, Elvire; S. Kim, Rim; Michiels, Stefan; D. Gallas, Brandon; Chen, Weijie; Van de Vijver, Koen; Goel, Shom; Adams, Sylvia; Demaria, Sandra; Viale, Giuseppe; O. Nielsen, Torsten; Badve, Sunil; Fraser Symmans, W.; Sotiriou, Christos; L. Rimm, David; M. Hewitt, Stephen; Denkert, Carsten; Loibl, Sibylle; J. Luen, Stephen; M. S. Bartlett, John; Savas, Peter; Pruneri, Giancarlo; Dillon, Deborah; C.U. Cheang, Maggie; Tutt, Andrew; A. Hall, Jacqueline; Kok, Marleen; M. Horlings, Hugo; Madabhushi, Anant; van der Laak, Jeroen; Ciompi, Francesco; Lænkholm, Anne‐Vibeke; Bellolio, Enrique; Gruosso, Tina; B. Fox, Stephen; Carlos Araya, Juan; Floris, Giuseppe; Hudeček, Jan; Voorwerk, Leonie; H. Beck, Andrew; Kaplan Kerner, J.; Larsimont, Denis; Declercq, Sabine; Van den Eynden, Gert; Pusztai, Lajos; Ehinger, Anna; Yang, Wentao; AbdulJabbar, Khalid; Yuan, Yinyin; Singh, Rajendra; T. Hiley, Crispin; Al Bakir, Maise; J. Lazar, Alexander; P. Naber, Stephen; Wienert, Stephan; Castillo, Miluska; Curigliano, Giuseppe; Vittoria Dieci, Maria; André, Fabrice; Swanton, Charles; S. Reis‐Filho, Jorge; A. Sparano, Joseph; Balslev, Eva; Chen, I‐Chun; Ida Specht Stovgaard, Elisabeth; L. Pogue–Geile, Katherine; Blenman, Kim; Penault–Llorca, Frédérique; J. Schnitt, Stuart; R. Lakhani, Sunil; Vincent‐Salomon, Anne; Rojo, Federico; Braybrooke, Jeremy; G. Hanna, Matthew; Teresa Soler-Monsó, María; Bethmann, Daniel; Castaneda, Carlos; Willard‐Gallo, Karen; Sharma, Ashish; Lien, Huang‐Chun; Fineberg, Susan; Thagaard, Jeppe; Comerma, Laura; I. González-Ericsson, Paula; Brogi, Edi; Loi, Sherene; Saltz, Joel; Klaushen, Frederick; Cooper, Lee; Amgad, Mohamed; Moore, David; Salgado, Roberto; International Immuno-Oncology Biomarker Working Group, the; Hyytiäinen, Aini; I. Hida, Akira; Thompson, Alastair; Lefevre, Alexis; M. Gown, Allen; Lo, Amy; Sapino, Anna; Moreira, André; L. Richardson, Andrea; Vingiani, Andrea; M. Bellizzi, Andrew; Guerrero, Ángel; Grigoriadis, Anita; C. Garrido-Castro, Ana; Cimino‐Mathews, Ashley; Srinivasan, Ashok; Ács, Balázs; Singh, Baljit; C. Calhoun, Benjamin; Haibe-Kans, Benjamin; Solomon, Benjamin; Thapa, Bibhusal; H. Nelson, Brad; Ballesteroes-Merino, Carmen; Criscitiello, Carmen; Boeckx, Carolien; Colpaert, Cécile; Quinn, Cecily; S. Chennubhotla, Chakra; Solinas, Cinzia; Drubay, Damien; Sabanathan, Dhanusha; Peeters, Dieter; Zardavas, Dimitrios; Höflmayer, Doris; B. Johnson, Douglas; Aubrey Thompson, E.; Perez, Edith; A. ElGabry, Ehab; F. Blackley, Elizabeth; Reisenbichler, Emily; Chmielik, Ewa; Gaire, Fabien; Lu, Fang-I; Azmoudeh Ardalan, Farid; Peale, Franklin; R Hirsch, Fred; Acosta-Haab, Gabriela; Farshid, Gelareh; Broeckx, Glenn; Koeppen, Harmut; R. Haynes, Harry; L. McArthur, Heather; Joensuu, Heikki; Olofsson, Helena; A. Cree, Ian; Nederlof, Iris; Frahm, Isabel; Brčić, Iva; Junjie Chan, Jack; Ziai, James; Brock, Jane; Weseling, Jelle; M. Giltnane, Jennifer; Lemonnier, Jérôme; Zha, Jiping; Ribeiro, Joana; K. Lennerz, Jochen; M. Carter, Jodi; Hartman, Johan; A. Hainfellner, Johannes; Le Quesne, John; Juco, Jonathan; van den Berg, José; Sanchez, Joselyn; Cucherousset, Joël; Adam, Julien; M. Balko, Justin; Saeger, Kai; P. Siziopikou, Kalliopi; Sikorska, Karolina; E. Weber, Karsten; E. Steele, Keith; Emancipator, Kenneth; El Bairi, Khalid; H. Allison, Kimberly; Korski, Konstanty; Buisseret, Laurence; Shi, Leming; Kooreman, Loes; Molinero, Luciana; V. Estrada, Mónica; van Seijen, Maartje; Lacroix‐Triki, Magali; Sebastian, Manu; Luiz Balancin, Marcelo; Mathieu, Marie‐Christine; J. van de Vijver, Marc; C. Rebelatto, Marlon; Piccart, Martine; P. Goetz, Matthew; Preusser, Matthias; Khojasteh, Mehrnoush; E. Sanders, Melinda; M. Regan, Meredith; Barnes, Michael; Christie, Michael; J. Misialek, Michael; Ignatiadis, Michail; de Maaker, Michiel; Van Bockstal, Mieke; Harbeck, Nadia; Tung, Nadine; Laudus, Nele; Sirtaine, Nicolas; Burchardi, Nicole; Ternès, Nils; Radosevic‐Robin, Nina; Gluz, Oleg; Grimm, Oliver; Nucíforo, Paolo; Jank, Paul; Kirtani, Pawan; H. Watson, Peter; Jelinic, Peter; A. Francis, Prudence; A. Russell, Prudence; H. Pierce, Robert; K. Hills, Robert; A. Leon‐Ferre, Roberto; de Wind, Roland; Shui, Ruohong; Leung, Samuel; Tabbarah, Sami; C. Souza, Sandra; A. O’Toole, Sandra; M. Swain, Sandra; Dudgeon, Sarah; Willis, Scooter; Ely, Scott; Bedri, Shahinaz; Irshad, Sheeba; Liu, Shiwei; Hendry, Shona; Bianchi, Simonetta; Bragança, Sofia; Paik, Soonmyung; Luz, Sua; Gevaert, Thomas; d’Alfons, Timothy; John, Tom; Sugie, Tomohagu; Kurkure, Uday; Bossuyt, Veerle; Manem, Venkata; Peg Cámaea, Vincente; Tong, Weida; T. Tran, William; Wang, Yihong; Allory, Yves; Husain, Zaheed; Bagó-Horváth, Zsuzsanna

doi:10.1038/s41523-020-0156-0

Public

Pitfalls in assessing stromal tumor infiltrating lymphocytes (sTILs) in breast cancer

Published in npj Breast Cancer • May 12, 2020

Authors:

Zuzana Kos

Elvire Roblin

Rim S. Kim

Abstract

Stromal tumor-infiltrating lymphocytes (sTILs) are important prognostic and predictive biomarkers in triple-negative (TNBC) and HER2-positive breast cancer. Incorporating sTILs into clinical practice necessitates reproducible assessment. Previously developed standardized scoring guidelines have been...

Subject

Breast cancer

Cancer

Medicine

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