Fr-PPIChem: An Academic Compound Library Dedicated to Protein–Protein Interactions

Bosc, Nicolas; Müller, Christophe; Hoffer, Laurent; Lagorce, David; Bourg, Stéphane; Derviaux, Carine; Gourdel‐Martin, Marie‐Edith; Rain, Jean‐Christophe; W. Miller, Thomas; O. Villoutreix, Bruno; A. Miteva, Maria; Bonnet, Pascal; Morelli, Xavier; Spérandio, Olivier; Roche, Philippe

doi:10.1021/acschembio.0c00179

Public

Fr-PPIChem: An Academic Compound Library Dedicated to Protein–Protein Interactions

Published in ACS Chemical Biology • Apr 22, 2020

Authors:

Nicolas Bosc

Christophe Müller

Laurent Hoffer

Abstract

Protein-protein interactions (PPIs) mediate nearly every cellular process and represent attractive targets for modulating disease states but are challenging to target with small molecules. Despite this, several PPI inhibitors (iPPIs) have entered clinical trials, and a growing number of PPIs have be...

Subject

Chemical library

Computer science

Drug discovery

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