The Set7 Lysine Methyltransferase Regulates Plasticity in Oxidative Phosphorylation Necessary for Trained Immunity Induced by β-Glucan

T. Keating, Samuel; Groh, Laszlo; D.C.C. van der Heijden, Charlotte; Rodriguez, Hanah; Cristina dos Santos, Jéssica; Fanucchi, Stephanie; Okabe, Jun; Kaipananickal, Harikrishnan; H. van Puffelen, Jelmer; Helder, Leonie; P. Noz, Marlies; Matzaraki, Vasiliki; Li, Yang; Charlotte J. de Bree, L.; A. C. M. Koeken, Valerie; J.C.F.M. Moorlag, Simone; P. Mourits, Vera; Domínguez‐Andrés, Jorge; Oosting, Marije; P. Bulthuis, Elianne; J.H. Koopman, Werner; M. Mhlanga, Musa; El‐Osta, Assam; A. B. Joosten, Leo; G. Netea, Mihai; P. Riksen, Niels

doi:10.1016/j.celrep.2020.107548

Public

The Set7 Lysine Methyltransferase Regulates Plasticity in Oxidative Phosphorylation Necessary for Trained Immunity Induced by β-Glucan

Published in Cell Reports • Apr 1, 2020

Authors:

Samuel T. Keating

Laszlo Groh

Charlotte D.C.C. van der Heijden

Abstract

Trained immunity confers a sustained augmented response of innate immune cells to a secondary challenge, via a process dependent on metabolic and transcriptional reprogramming. Because of its previous associations with metabolic and transcriptional memory, as well as the importance of H3 histone lys...

Subject

Innate immune system

Immunity

Biology

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