&lt;p&gt;Transferrin-Modified Osthole PEGylated Liposomes Travel the Blood-Brain Barrier and Mitigate Alzheimer’s Disease-Related Pathology in APP/PS-1 Mice&lt;/p&gt;

Kong, Liang; Li, Xuetao; Ni, Yingnan; Xiao, Honghe; Yao, Yingjia; Wang, Yuan-yuan; Ju, Rui-Jun; Li, Hongyan; Liu, Jingjing; Fu, Min; Wu, Yutong; Yang, Jingxian; Cheng, Lan

doi:10.2147/ijn.s239608

Public

<p>Transferrin-Modified Osthole PEGylated Liposomes Travel the Blood-Brain Barrier and Mitigate Alzheimer’s Disease-Related Pathology in APP/PS-1 Mice</p>

Published in International Journal of Nanomedicine • Apr 1, 2020

Authors:

Liang Kong

Xuetao Li

Yingnan Ni

Abstract

INTRODUCTION: Osthole (Ost) is a coumarin compound that strengthens hippocampal neurons and neural stem cells against Aβ oligomer-induced neurotoxicity in mice, and is a potential drug for the treatment of Alzheimer's disease (AD). However, the effectiveness of the drug is limited by its solubility ...

Subject

Blood–brain barrier

Pharmacology

In vivo

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