Versatile whole-organ/body staining and imaging based on electrolyte-gel properties of biological tissues

A. Susaki, Etsuo; Shimizu, Chika; Kuno, Akihiro; Tainaka, Kazuki; Li, Xiang; Nishi, Kengo; Morishima, Ken; Ono, Hiroaki; L. Ode, Koji; Saeki, Yuki; Miyamichi, Kazunari; Isa, Kaoru; Yokoyama, Chihiro; Kitaura, Hiroki; Ikemura, Masako; Ushiku, Tetsuo; Shimizu, Yoshihiro; Saito, Takashi; C. Saido, Takaomi; Fukayama, Masashi; Onoe, Hirotaka; Touhara, Kazushige; Isa, Tadashi; Kakita, Akiyoshi; Shibayama, Mitsuhiro; R. Ueda, Hiroki

doi:10.1038/s41467-020-15906-5

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Versatile whole-organ/body staining and imaging based on electrolyte-gel properties of biological tissues

Shared by NobleBlocks on Apr 27, 2020 • 12:00 AM UTC

Authors:

Etsuo A. Susaki

Chika Shimizu

Akihiro Kuno

Abstract

Abstract Whole-organ/body three-dimensional (3D) staining and imaging have been enduring challenges in histology. By dissecting the complex physicochemical environment of the staining system, we developed a highly optimized 3D staining imaging pipeline based on CUBIC. Based on our precise characteri...

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