Emerging SARS-CoV-2 mutation hot spots include a novel RNA-dependent-RNA polymerase variant

Pachetti, Maria; Marini, Bruna; Benedetti, Francesca; Giudici, Fabiola; Mauro, Elisabetta; Storici, Paola; Masciovecchio, C.; Angeletti, Silvia; Ciccozzi, Massimo; C. Gallo, Robert; Zella, Davide; Ippodrino, Rudy

doi:10.1186/s12967-020-02344-6

Public

Emerging SARS-CoV-2 mutation hot spots include a novel RNA-dependent-RNA polymerase variant

Published in Journal of Translational Medicine • Apr 22, 2020

Authors:

Maria Pachetti

Bruna Marini

Francesca Benedetti

Abstract

BACKGROUND: SARS-CoV-2 is a RNA coronavirus responsible for the pandemic of the Severe Acute Respiratory Syndrome (COVID-19). RNA viruses are characterized by a high mutation rate, up to a million times higher than that of their hosts. Virus mutagenic capability depends upon several factors, includi...

Subject

Mutation

Point mutation

Virology

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