Effect of High vs Low Doses of Chloroquine Diphosphate as Adjunctive Therapy for Patients Hospitalized With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection

Gabriela Silva Borba, Mayla; Val, Fernando; de Souza Sampaio, Vanderson; Almeida Araújo Alexandre, Márcia; Cardoso de Melo, Gisely; Augusto Mota Brito, Marcelo; Paula Gomes Mourão, Maria; Diego Brito-Sousa, José; Clarys Baía-da-Silva, Djane; Vinitius Farias Guerra, Marcus; Abrahão Hajjar, Ludhmila; Costa Pinto, Rosemary; Alcirley Silva Balieiro, Antonio; Guilherme Pacheco, Antônio; Dean Oliveira dos Santos, James; Gomes Naveca, Felipe; Simão Xavier, Mariana; M. Siqueira, André; Vargas Schwarzbold, Alexandre; Croda, Júlio; Lacerda Nogueira, Maurício; Adolfo Sierra Romero, Gustavo; Bassat, Quique; Jésus Fernandes Fontes, Cor; Cláudio de Albuquerque, Bernardino; Daniel-Ribeiro, Cláudio-Tadeu; Marcelo Monteiro, Wuelton; Lacerda, Marcus; the CloroCovid-19 Team, for

doi:10.1001/jamanetworkopen.2020.8857

Public

Effect of High vs Low Doses of Chloroquine Diphosphate as Adjunctive Therapy for Patients Hospitalized With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection

Published in JAMA Network Open • Apr 24, 2020

Authors:

Mayla Gabriela Silva Borba

Fernando Val

Vanderson de Souza Sampaio

Abstract

Importance: There is no specific antiviral therapy recommended for coronavirus disease 2019 (COVID-19). In vitro studies indicate that the antiviral effect of chloroquine diphosphate (CQ) requires a high concentration of the drug. Objective: To evaluate the safety and efficacy of 2 CQ dosages in pat...

Subject

Medicine

Chloroquine

Hydroxychloroquine

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