Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease

Dai, Wenhao; Zhang, Bing; Jiang, Xia-Ming; Su, Haixia; Li, Jian; Zhao, Yao; Xie, Xiong; Jin, Zhenming; Peng, Jingjing; Liu, Fengjiang; Li, Chunpu; Li, You; Bai, Fang; Wang, Haofeng; Cheng, Xi; Cen, Xiaobo; Hu, Shulei; Yang, Xiuna; Wang, Jiang; Liu, Xiang; Xiao, Gengfu; Jiang, Hualiang; Rao, Zihe; Zhang, Leike; Xu, Yechun; Yang, Haitao; Liu, Hong

doi:10.1126/science.abb4489

Public

Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease

Published in Science • Apr 22, 2020

Authors:

Wenhao Dai

Bing Zhang

Xia-Ming Jiang

Abstract

Promising antiviral protease inhibitors With no vaccine or proven effective drug against the virus that causes coronavirus disease 2019 (COVID-19), scientists are racing to find clinical antiviral treatments. A promising drug target is the viral main protease M pro , which plays a key role in viral ...

Subject

Coronavirus

Protease

Antiviral drug

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