Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2

Monteil, Vanessa; Kwon, Hyesoo; Prado, Patricia; Hagelkrüys, Astrid; Wimmer, Reiner; Ståhl, Martin; Leopoldi, Alexandra; Garreta, Elena; Hurtado del Pozo, Carmen; Prósper, Felipe; P. Romero, Juan; Wirnsberger, Gerald; Zhang, Haibo; S. Slutsky, Arthur; Conder, Ryan; Montserrat, Núria; Mirazimi, Alì; Penninger, Josef

doi:10.1016/j.cell.2020.04.004

Public

Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2

Published in Cell • Apr 24, 2020

Authors:

Vanessa Monteil

Hyesoo Kwon

Patricia Prado

Abstract

We have previously provided the first genetic evidence that angiotensin converting enzyme 2 (ACE2) is the critical receptor for severe acute respiratory syndrome coronavirus (SARS-CoV), and ACE2 protects the lung from injury, providing a molecular explanation for the severe lung failure and death du...

Subject

Biology

Vero cell

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

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