Single-Cell Transcriptome Analysis Reveals Intratumoral Heterogeneity in ccRCC, which Results in Different Clinical Outcomes

Hu, Junyi; Chen, Zhaohui; Bao, Lin; Zhou, Lijie; Hou, Yaxin; Liu, Lilong; Xiong, Ming; Zhang, Yuhan; Wang, Bin; Tao, Zhen; Chen, Ke

doi:10.1016/j.ymthe.2020.04.023

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Single-Cell Transcriptome Analysis Reveals Intratumoral Heterogeneity in ccRCC, which Results in Different Clinical Outcomes

Published in Molecular Therapy • Apr 29, 2020

Authors:

Junyi Hu

Zhaohui Chen

Lin Bao

Abstract

Clear-cell renal cell carcinoma (ccRCC) is the most common histological type of RCC. To investigate the intratumoral heterogeneity of ccRCC, we analyzed single-cell RNA-sequencing data and identified 15 major cell types, along with 39 subgroups of cells derived from tumor or non-malignant tissues, a...

Subject

Transcriptome

Biology

Computational biology

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