A vinylogous Michael reaction of 2-furanone dimers with α,β-unsaturated nitroolefins for constructing chiral γ,γ-disubstituted butenolides

Bai, Zhushuang; Zhang, Cai‐Rong; Chen, Yongyi; Liu, Aiqin; Wang, Xinyu; Wang, Xinyu; Yan, Chuna; Liu, Xuechao; Zhang, Xiaoru; Li, Ying; Yuan, Ye; Ge, Zemei; Pang, Jingxiang; Chai, Yongshuai; Wang, Xin; Wang, Xin; Li, Runtao

doi:10.1039/d0qo00376j

Public

A vinylogous Michael reaction of 2-furanone dimers with α,β-unsaturated nitroolefins for constructing chiral γ,γ-disubstituted butenolides

Published in Organic Chemistry Frontiers • Jan 1, 2020

Authors:

Zhushuang Bai

Cai‐Rong Zhang

Yongyi Chen

Abstract

An asymmetric vinylogous Michael reaction of 2-furanone dimers with α,β-unsaturated nitroolefins utilizing bifunctional thiourea as a catalyst has been developed, which provides an easy access to a wide range of chiral γ,γ-disubstituted butenolides.

Subject

Bifunctional

Chemistry

Thiourea

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