Lipopolysaccharides transport during fat absorption in rodent small intestine

Akiba, Yasutada; Maruta, Koji; Takajo, Takeshi; Narimatsu, Kazuyuki; Said, Hyder; Kato, Ikuo; Kuwahara, Atsukazu; D. Kaunitz, Jonathan

doi:10.1152/ajpgi.00079.2020

Public

Lipopolysaccharides transport during fat absorption in rodent small intestine

Published in American Journal of Physiology-Gastrointestinal and Liver Physiology • May 11, 2020

Authors:

Yasutada Akiba

Koji Maruta

Takeshi Takajo

Abstract

We report direct in vivo confirmation of transcellular lipopolysaccharides (LPS) uptake from the intestine into the portal vein (PV) involving CD36 and lipid rafts, with minor uptake via the canonical chylomicron pathway. The gut hormone glucagon-like peptide-2 (GLP-2) inhibited uptake into the PV. ...

Subject

Paracellular transport

Transcellular

Chylomicron

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