Emapalumab in Children with Primary Hemophagocytic Lymphohistiocytosis

Locatelli, Franco; B. Jordan, Michael; E. Allen, Carl; Cesaro, Simone; Rizzari, Carmelo; Rao, Anupama; Degar, Barbara; Garrington, Timothy; Sevilla, Julián; C Putti, M; Fagioli, Franca; Ahlmann, Martina; Dapena Diaz, Jose-Luis; M Henry, M; De Benedetti, Fabrizio; A. Grom, Alexei; Lapeyre, G; Jacqmin, Philippe; Ballabio, Maria; de Min, Cristina

doi:10.1056/nejmoa1911326

Public

Emapalumab in Children with Primary Hemophagocytic Lymphohistiocytosis

Published in New England Journal of Medicine • May 6, 2020

Authors:

Franco Locatelli

Michael B. Jordan

Carl E. Allen

Abstract

BACKGROUND: Primary hemophagocytic lymphohistiocytosis is a rare syndrome characterized by immune dysregulation and hyperinflammation. It typically manifests in infancy and is associated with high mortality. METHODS: We investigated the efficacy and safety of emapalumab (a human anti-interferon-γ an...

Subject

Hemophagocytic lymphohistiocytosis

Primary (astronomy)

Medicine

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