The structural differences between patient-derived α-synuclein strains dictate characteristics of Parkinson’s disease, multiple system atrophy and dementia with Lewy bodies

Van der Perren, Anke; Gelders, Géraldine; Fenyi, Alexis; Bousset, Luc; Brito, Filipa; Peelaerts, Wouter; Van den Haute, Chris; Gentleman, Steve; Melki, Ronald; Baekelandt, Veerle

doi:10.1007/s00401-020-02157-3

Public

The structural differences between patient-derived α-synuclein strains dictate characteristics of Parkinson’s disease, multiple system atrophy and dementia with Lewy bodies

Published in Acta Neuropathologica • Apr 30, 2020

Authors:

Anke Van der Perren

Géraldine Gelders

Alexis Fenyi

Abstract

Synucleinopathies, such as Parkinson's disease (PD), multiple system atrophy (MSA), and dementia with Lewy bodies (DLB), are defined by the presence of α-synuclein (αSYN) aggregates throughout the nervous system but diverge from one another with regard to their clinical and pathological phenotype. T...

Subject

Dementia with Lewy bodies

Parkinson's disease

Atrophy

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