Levetiracetam Versus Phenobarbital for Neonatal Seizures: A Randomized Controlled Trial

Sharpe, Cynthia; Reiner, Gail; L. Davis, Suzanne; Nespeca, Mark; J. Gold, Jeffrey; R. Rasmussen, Maynard; Kuperman, Rachel; Jo Harbert, Mary; Michelson, David; Joe, Priscilla; Wang, Sonya; Rismanchi, Neggy; Minh Lê, Ngọc; Mower, Andrew; Kim, Jae; Battin, Malcolm; Lane, Brian; Honold, Jose; Knodel, Ellen; Arnell, Kathy; Bridge, Renee; Lee, Lilly; Ernström, Karin; Raman, Rema; Haas, Richard; THE NEOLEV2 INVESTIGATORS, FOR

doi:10.1542/peds.2019-3182

Public

Levetiracetam Versus Phenobarbital for Neonatal Seizures: A Randomized Controlled Trial

Published in PEDIATRICS • May 8, 2020

Authors:

Cynthia Sharpe

Gail Reiner

Suzanne L. Davis

Abstract

BACKGROUND AND OBJECTIVES: There are no US Food and Drug Administration-approved therapies for neonatal seizures. Phenobarbital and phenytoin frequently fail to control seizures. There are concerns about the safety of seizure medications in the developing brain. Levetiracetam has proven efficacy and...

Subject

Levetiracetam

Medicine

Phenobarbital

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