Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir

Yin, Wanchao; Mao, Chunyou; Luan, Xiaodong; Shen, Dandan; Shen, Qingya; Su, Haixia; Wang, Xiaoxi; Zhou, Fulai; Zhao, Wenfeng; Gao, Minqi; Chang, Shenghai; Xie, Yuanchao; Tian, Guanghui; Jiang, He‐wei; Tao, Sheng‐ce; Shen, Jingshan; Jiang, Yi; Jiang, Hualiang; Xu, Yechun; Zhang, Shuyang; Zhang, Yan; Eric Xu, H.

doi:10.1126/science.abc1560

Public

Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir

Published in Science • May 1, 2020

Authors:

Wanchao Yin

Chunyou Mao

Xiaodong Luan

Abstract

The pandemic of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become a global crisis. Replication of SARS-CoV-2 requires the viral RNA-dependent RNA polymerase (RdRp) enzyme, a target of the antiviral drug remdesivir. Here we report ...

Subject

RNA-dependent RNA polymerase

RNA

RNA polymerase

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