High-risk additional chromosomal abnormalities at low blast counts herald death by CML

Hehlmann, Rüdiger; Voskanyan, Astghik; Lauseker, Michael; Pfirrmann, Markus; Kalmanti, Lida; Rinaldetti, Sébastien; Kohlbrenner, Katharina; Haferlach, Claudia; Schlegelberger, Brigitte; Fabarius, Alice; Seifarth, Wolfgang; Spieß, Birgit; Wuchter, Patrick; W. Krause, Stefan; Kolb, Hans‐Jochem; Neubauer, Andreas; K. Hossfeld, Dieter; Nerl, Christoph; Gratwohl, Aloïs; M. Baerlocher, Gabriela; Burchert, Andreas; H. Brümmendorf, Tim; Hasford, Jörg; Hochhaus, Andreas; Saußele, Susanne; Baccarani, Michele; the SAKK and the German CML Study Group, for; Fischer von Weikersthal, Ludwig; Hahn, Markus; Schlimok, Günter; Reichert, Dietmar; Janßen, Jan; M. Martens, Uwe; Majunke, Peter; Reichert, Peter; Neben, Kai; Korsten, Stefan; Scholz, Ch.; Oldenkott, Bernd; Heßling, Jörg; Kingreen, D.; Sperling, Christian; Schelenz, C.; W. Blau, I.; Urmersbach, A.; D. Ludwig, W.; le Coutre, Philipp; Arnold, R.; de Wit, Maike; Pezzutto, Antonio; Schäfer, E.; Schroers, Roland; Lochter, A.; Behringer, Dirk; Ko, Y.; Weidenhöfer, St.; Verbeek, Walter; Brossart, Peter; Trenn, Guido; Pommerien, W; Krauter, J.; Döering, G.; Munzinger, H.; Diekmann, C.; Hertenstein, Bernd; Stier, Sebastian; Möller-Faßbender, F.; Hänel, Mathias; Zöller, T.; Lamberti, C.; Koch, Babette; Henzel, A.; Wagner, Siegfried; Schmalenbach, A.; Hoffknecht, M.; Ehninger, Gerhard; Kiani, Alexander; Illmer, Thomas; Aul, Carlo; Flaßhove, Michael; Henneke, F.; Simon, M.; Müller, Lothar; Becker, Heiko; F. Janz, R.; J. Eckart, Michael; J. Fuchs, Roland; Schlegel, Frank; Amen Wattad, Mohammad; Rudolph, R.; W. Beelen, Dietrich; Lindemann, A; Linck, D.; , Wassman; Jäger, Elke; Al‐Batran, Salah‐Eddin; Reiber, T; F. Waller, Cornelius; Hoeffkes, Heinz‐Gert; Schulz, L.S.; Tajrobehkar, K.; Mittermüller, J.; Pralle, H.; Runde, V.; Hoyer, Annika; Tessen, H.; Trümper, Lorenz; Schmidt, Christian; Sieber, M.; Eschenburg, H.; Depenbusch, Reinhard; Rösel, Siegfried; W. Lindemann, H.; Wolf, H.; Spohn, C.; Moeller, Regina; K. Hossfeld, D.; Zander, A.; Schafhausen, Philippe; Koster, Harry; Hollburg, Wiebke; Schmitz, Norbert; Dürk, Heinz; Hemeier, M.; Grote-Metke, A.; Weischer, H.; Bechtel, Benjamin; Balleisen, L.; Sosada, Markus; D. Ho, Anthony; Petersen, Volker; Dengler, Jolanta; Bildat, Stephan; Hahn, Lars; Dietzfelbinger, Hermann; Gröschel, W.; Bartholomäus, A.; Freier, Werner; Sievers, B; Pfreundschuh, I.-M.; Herrmann, Tressie; A. Fauser, A.; Menzel, J.; Kemmerling, M.; M. Hansen, Richard; Link, Hartmut; Schatz, Michael; Bentz, Martin; Prümmer, Otto; Kneba, Michael; Heymanns, Jochen; Schmitz, S.; Scheid, C.; Lollert, André; Neise, Michael; Planker, M.; Stauch, Martina; Schröder, M.; Kempf, B.; Vehling‐Kaiser, Ursula; Kremers, Stephan; Köchling, Georg; Müller, Lothar; Hartmann, Frank; Neuhaus, T.; Fetscher, Sebastian; Kämpfe, D.; Heil, Gerhard; Uppenkamp, M.; Goldmann, Bernhard; Fischer Huber, T.; Hieber, U.; Plöger, Christoph; Grießhammer, Martin; S. Lange, Christopher; Göttler, B.; Lunscken, C.; Schiel, Xaver; Scheidegger, Claude; Stötzer, Oliver; Hitz, H.; Schick, H.; Völkl, S.; Spiekermann, Karsten; Berdel, W; Hebart, Holger; Ladda, Ekkehart; Schmidt, P.; Burkhardt, U.; Hentschke, S.; Falge, Christiane; Reschke, D.; Köhne, Claus-Henning; Müller‐Naendrup, Clemens; Sauer, Maik; Frühauf, S.; Ranft, K; Dencausse, Y.; Sandritter, Bettina; Baake, G.; Hofknecht, M.; Dengler, Robert; Edinger, Matthias; Schenk, Michael; Wehmeier, A.; Weidelich, H.-P.; Pihusch, Rudolf; Stahlhut, Kerstin; Baldus, M.; Matzdorff, Axel; Geer, Thomas; Schanz, Stefan; Käfer, G.; Gaßmann, W.; Priebe-Richter, C.; Demandt, M.; Springer, Gayle; Fiechtner, Heinrich; Denzlinger, Claudio; Schleicher, Jan; Assman, D.; Gaeckler, R.; E. Adam, Gina; Reza Waladkhani, Ali; Rendenbach, Bernhard; Forstbauer, Helmut; Kanz, Lothar; Jacki, Swen; Stegelmann, Frank; Kalhori, Niakan; Nusch, Arud; Langer, W.; Müller, F.; Brettner, Stefan; Uebelmesser, B.; Kamp, T.; Schadeck-Gressel, C.; Josten, K.; D. Klein, Ophir; Schwerdtfeger, Rainer; Baurmann, H.; Strotkötter, H.; Fett, W.; Raghavachar, Aruna; Maintz, Christoph; C. Goebler, M.; Schlag, Rudolf; Elsel, W.; Wernli, Martin; Heim, Dominik; A. Wuillemin, Walter; Hess, U; Gmür, J; Mayer, Jiří

doi:10.1038/s41375-020-0826-9

Public

High-risk additional chromosomal abnormalities at low blast counts herald death by CML

Published in Leukemia • May 7, 2020

Authors:

Rüdiger Hehlmann

Astghik Voskanyan

Michael Lauseker

Abstract

Blast crisis is one of the remaining challenges in chronic myeloid leukemia (CML). Whether additional chromosomal abnormalities (ACAs) enable an earlier recognition of imminent blastic proliferation and a timelier change of treatment is unknown. One thousand five hundred and ten imatinib-treated pat...

Subject

Medicine

Internal medicine

Hazard ratio

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