Key residues of the receptor binding motif in the spike protein of SARS-CoV-2 that interact with ACE2 and neutralizing antibodies

Yi, Chunyan; Sun, Xiaoyu; Ye, Jing; Ding, Longfei; Liu, Meiqin; Yang, Zhuo; Lü, Xiaoxia; Zhang, Yaguang; Ma, Liyang; Gu, Wangpeng; Qu, Aidong; Xu, Jianqing; Shi, Zhengli; Ling, Zhiyang; Sun, Bing

doi:10.1038/s41423-020-0458-z

Public

Key residues of the receptor binding motif in the spike protein of SARS-CoV-2 that interact with ACE2 and neutralizing antibodies

Published in Cellular and Molecular Immunology • May 15, 2020

Authors:

Chunyan Yi

Xiaoyu Sun

Jing Ye

Abstract

Coronavirus disease 2019 (COVID-19), caused by the novel human coronavirus SARS-CoV-2, is currently a major threat to public health worldwide. The viral spike protein binds the host receptor angiotensin-converting enzyme 2 (ACE2) via the receptor-binding domain (RBD), and thus is believed to be a ma...

Subject

Virology

Epitope

Antibody

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