Targeting Aquaporin-4 Subcellular Localization to Treat Central Nervous System Edema

Kitchen, Philip; M. Salman, Mootaz; Halsey, Andrea; Clarke-Bland, Charlotte; A. MacDonald, Justin; Ishida, Hiroaki; J. Vogel, Hans; Almutiri, Sharif; Logan, Ann; Kreida, Stefan; Al-Jubair, Tamim; Winkel Missel, Julie; Gourdon, Pontus; Törnroth‐Horsefield, Susanna; T. Conner, Matthew; Ahmed, Zubair; C. Conner, Alex; M. Bill, Roslyn

doi:10.1016/j.cell.2020.03.037

Public

Targeting Aquaporin-4 Subcellular Localization to Treat Central Nervous System Edema

Published in Cell • May 1, 2020

Authors:

Philip Kitchen

Mootaz M. Salman

Andrea Halsey

Abstract

Swelling of the brain or spinal cord (CNS edema) affects millions of people every year. All potential pharmacological interventions have failed in clinical trials, meaning that symptom management is the only treatment option. The water channel protein aquaporin-4 (AQP4) is expressed in astrocytes an...

Subject

Aquaporin 4

Trifluoperazine

Central nervous system

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