A CX3CR1 Reporter hESC Line Facilitates Integrative Analysis of In-Vitro-Derived Microglia and Improved Microglia Identity upon Neuron-Glia Co-culture.

Grubman, Alexandra; H Vandekolk, Teresa; Schröder, Jan; Sun, Guizhi; Hatwell-Humble, Jessica; Chan, Jonathan; Oksanen, Minna; Lehtonen, Sarka; Hunt, Cameron; E Koistinaho, Jari; K Nilsson, Susan; M Haynes, John; W Pouton, Colin; M Polo, Jose

doi:10.1016/j.stemcr.2020.04.007

Public

A CX3CR1 Reporter hESC Line Facilitates Integrative Analysis of In-Vitro-Derived Microglia and Improved Microglia Identity upon Neuron-Glia Co-culture.

Shared by NobleBlocks on Jun 9, 2020 • 12:00 AM UTC

Authors:

Alexandra Grubman

Teresa H Vandekolk

Jan Schröder

Abstract

Multiple protocols have been published for generation of iMGLs from hESCs/iPSCs. To date, there are no guides to assist researchers to determine the most appropriate methodology for microglial studies. To establish a framework to facilitate future microglial studies, we first performed a comparative...

Subject

PSC differentiation

RNA-seq

in-vitro-derived microglia

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