BRCA1 Promoter Methylation and Clinical Outcomes in Ovarian Cancer: An Individual Patient Data Meta-Analysis.

RD, Kalachand; B, Stordal; S, Madden; B, Chandler; J, Cunningham; EL, Goode; I, Ruscito; EI, Braicu; J, Sehouli; A, Ignatov; H, Yu; D, Katsaros; GB, Mills; KH, Lu; MS, Carey; KM, Timms; J, Kupryjanczyk; IK, Rzepecka; A, Podgorska; JN, McAlpine; EM, Swisher; SS, Bernards; C, O'Riain; S, O'Toole; JJ, O'Leary; DD, Bowtell; DM, Thomas; K, Prieske; SA, Joosse; L, Woelber; P, Chaudhry; N, Häfner; IB, Runnebaum; BT, Hennessy

doi:10.1093/jnci/djaa070

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BRCA1 Promoter Methylation and Clinical Outcomes in Ovarian Cancer: An Individual Patient Data Meta-Analysis.

Shared by NobleBlocks on Dec 1, 2020 • 12:00 AM UTC

Authors:

Kalachand RD

Stordal B

Madden S

Abstract

Background BRCA1 methylation has been associated with homologous recombination deficiency, a biomarker of platinum sensitivity. Studies evaluating BRCA1-methylated tubal and ovarian cancer (OC) do not consistently support improved survival following platinum chemotherapy. We examine the characterist...

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