Single-Cell Analysis Reveals Fibroblast Clusters Linked to Immunotherapy Resistance in Cancer

Kieffer, Yann; R. Hocine, Hocine; Gentric, Géraldine; Pelon, Floriane; Bernard, Charles; Bourachot, Brigitte; Lameiras, Sonia; Albergante, Luca; Bonneau, Claire; Guyard, Alice; Tarte, Karin; Zinovyev, Andreï; Baulande, Sylvain; Zalcman, Gérard; Vincent‐Salomon, Anne; Mechta‐Grigoriou, Fatima

doi:10.1158/2159-8290.cd-19-1384

Public

Single-Cell Analysis Reveals Fibroblast Clusters Linked to Immunotherapy Resistance in Cancer

Published in Cancer Discovery • May 20, 2020

Authors:

Yann Kieffer

Hocine R. Hocine

Géraldine Gentric

Abstract

Abstract A subset of cancer-associated fibroblasts (FAP+/CAF-S1) mediates immunosuppression in breast cancers, but its heterogeneity and its impact on immunotherapy response remain unknown. Here, we identify 8 CAF-S1 clusters by analyzing more than 19,000 single CAF-S1 fibroblasts from breast cancer...

Subject

Immunotherapy

Breast cancer

Cancer research

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!