Tspan8 Drives Melanoma Dermal Invasion by Promoting ProMMP-9 Activation and Basement Membrane Proteolysis in a Keratinocyte-Dependent Manner

El Kharbili, Manale; Cario, Muriel; Béchetoille, Nicolas; Pain, C.; Boucheix, Claude; Degoul, Françoise; Masse, Ingrid; Berthier‐Vergnes, Odile

doi:10.3390/cancers12051297

Public

Tspan8 Drives Melanoma Dermal Invasion by Promoting ProMMP-9 Activation and Basement Membrane Proteolysis in a Keratinocyte-Dependent Manner

Published in Cancers • May 21, 2020

Authors:

Manale El Kharbili

Muriel Cario

Nicolas Béchetoille

Abstract

Melanoma is the most aggressive skin cancer with an extremely challenging therapy. The dermal-epidermal junction (DEJ) degradation and subsequent dermal invasion are the earliest steps of melanoma dissemination, but the mechanisms remain elusive. We previously identified Tspan8 as a key actor in mel...

Subject

Melanoma

Dermis

Keratinocyte

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