DNA vaccine protection against SARS-CoV-2 in rhesus macaques

Yu, Jingyou; H. Tostanoski, Lisa; Peter, Lauren; B. Mercado, Noe; McMahan, Katherine; H. Mahrokhian, Shant; P. Nkolola, Joseph; Liu, Jinyan; Li, Zhenfeng; Chandrashekar, Abishek; R. Martinez, David; Loos, Carolin; Atyeo, Caroline; Fischinger, Stephanie; S. Burke, John; D. Slein, Matthew; Chen, Yuezhou; Zuiani, Adam; Lelis, Felipe; Travers, Meghan; Habibi, Shaghayegh; Pessaint, Laurent; Van Ry, Alex; Blade, Kelvin; Brown, Renita; Cook, Anthony; Finneyfrock, Brad; Dodson, Alan; Teow, Elyse; Velasco, Jason; Zahn, Roland; Wegmann, Frank; A. Bondzie, Esther; Dagotto, Gabriel; S. Gebre, Makda; He, Xuan; Jacob-Dolan, Catherine; Kirilova, Marinela; Kordana, Nicole; Lin, Zijin; F. Maxfield, Lori; Nampanya, Felix; Nityanandam, Ramya; D. Ventura, John; Wan, Huahua; Cai, Yongfei; Chen, Bing; G. Schmidt, Aaron; R. Wesemann, Duane; S. Baric, Ralph; Alter, Galit; Andersen, Hanné; G. Lewis, Mark; H. Barouch, Dan

doi:10.1126/science.abc6284

Public

DNA vaccine protection against SARS-CoV-2 in rhesus macaques

Published in Science • May 20, 2020

Authors:

Jingyou Yu

Lisa H. Tostanoski

Lauren Peter

Abstract

Prototype DNA vaccines for SARS-CoV-2 The development of a vaccine to protect against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an urgent biomedical need. Yu et al. designed a series of prototype DNA vaccines against the SARS-CoV-2 spike protein, which is used by the virus to b...

Subject

Virology

DNA vaccination

Immune system

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