Clinical implications of serum neurofilament in newly diagnosed MS patients: A longitudinal multicentre cohort study

Bittner, Stefan; Steffen, Falk; Uphaus, Timo; Muthuraman, Muthuraman; Fleischer, Vinzenz; Salmen, Anke; Luessi, Felix; Berthele, Achim; Klotz, Luisa; G. Meuth, Sven; Bayas, Antonios; Paul, Friedemann; Hartung, Hans‐Peter; A. Linker, Ralf; Heesen, Christoph; Stangel, Martin; Wildemann, Brigitte; Then Bergh, Florian; Tackenberg, Björn; Kuempfel, Tania; Weber, Frank; K. Zettl, Uwe; Ziemann, Ulf; Tumani, Hayrettin; Groppa, Sergiu; Mühlau, Mark; Lukas, Carsten; Hemmer, Bernhard; Wiendl, Heinz; Gold, Ralf; Zipp, Frauke

doi:10.1016/j.ebiom.2020.102807

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Clinical implications of serum neurofilament in newly diagnosed MS patients: A longitudinal multicentre cohort study

Published in EBioMedicine • May 24, 2020

Authors:

Stefan Bittner

Falk Steffen

Timo Uphaus

Abstract

BACKGROUND: We aim to evaluate serum neurofilament light chain (sNfL), indicating neuroaxonal damage, as a biomarker at diagnosis in a large cohort of early multiple sclerosis (MS) patients. METHODS: In a multicentre prospective longitudinal observational cohort, patients with newly diagnosed relaps...

Subject

Medicine

Multiple sclerosis

Cohort

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