Functional Characterization of POFUT1 Variants Associated with Colorectal Cancer

Deschuyter, Marlène; Pennarubia, Florian; Pinault, Émilie; Legardinier, Sébastien; Maftah, Abderrahman

doi:10.3390/cancers12061430

Public

Functional Characterization of POFUT1 Variants Associated with Colorectal Cancer

Published in Cancers • May 31, 2020

Authors:

Marlène Deschuyter

Florian Pennarubia

Émilie Pinault

Abstract

Background: Protein O-fucosyltransferase 1 (POFUT1) overexpression, which is observed in many cancers such as colorectal cancer (CRC), leads to a NOTCH signaling dysregulation associated with the tumoral process. In rare CRC cases, with no POFUT1 overexpression, seven missense mutations were found i...

Subject

Colorectal cancer

Cancer

Computational biology

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