The human tumor microbiome is composed of tumor type–specific intracellular bacteria

Nejman, Deborah; Livyatan, Ilana; Fuks, Garold; Gavert, Nancy; Zwang, Yaara; T. Geller, Leore; Rotter-Maskowitz, Aviva; Weiser, Roi; Mallel, Giuseppe; Gigi, Elinor; Meltser, Arnon; M. Douglas, Gavin; Kamer, Iris; Gopalakrishnan, Vancheswaran; Dadosh, Tali; Levin‐Zaidman, Smadar; Avnet, Sofia; Atlan, Tehila; A. Cooper, Zachary; Arora, Reetakshi; P. Cogdill, Alexandria; Abdul Wadud Khan, Md; O Ologun, Gabriel; Bussi, Yuval; Weinberger, Adina; Lotan‐Pompan, Maya; Golani, Ofra; Perry, Gili; Rokah, Merav; Bahar‐Shany, Keren; A. Rozeman, Elisa; U. Blank, Christian; Ronai, Anat; Shaoul, Ron; Amit, Amnon; Dorfman, Tatiana; Kremer, Ran; R. Cohen, Zvi; Harnof, Sagi; Siegal, Tali; Yehuda‐Shnaidman, Einav; Nili Gal‐Yam, Einav; Shapira, Hagit; Baldini, Nicola; G. I. Langille, Morgan; Ben‐Nun, Alon; Kaufman, Bella; Nissan, Aviram; Golan, Talia; Dadiani, Maya; Levanon, Keren; Bar, Jair; Yust‐Katz, Shlomit; Barshack, Iris; S. Peeper, Daniel; J. Raz, Dan; Segal, Eran; A. Wargo, Jennifer; Sandbank, Judith; Shental, Noam; Straussman, Ravid

doi:10.1126/science.aay9189

Public

The human tumor microbiome is composed of tumor type–specific intracellular bacteria

Published in Science • May 28, 2020

Authors:

Deborah Nejman

Ilana Livyatan

Garold Fuks

Abstract

Bacteria were first detected in human tumors more than 100 years ago, but the characterization of the tumor microbiome has remained challenging because of its low biomass. We undertook a comprehensive analysis of the tumor microbiome, studying 1526 tumors and their adjacent normal tissues across sev...

Subject

Bacteria

Microbiome

Intracellular

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