TREM2 activation attenuates neuroinflammation and neuronal apoptosis via PI3K/Akt pathway after intracerebral hemorrhage in mice

Chen, Shengpan; Peng, Jianhua; Sherchan, Prativa; Ma, Yongjie; Xiang, Sishi; Yan, Feng; Zhao, Hao; Jiang, Yong; Wang, Ning; H. Zhang, John; Zhang, Hongqi

doi:10.1186/s12974-020-01853-x

Public

TREM2 activation attenuates neuroinflammation and neuronal apoptosis via PI3K/Akt pathway after intracerebral hemorrhage in mice

Published in Journal of Neuroinflammation • May 28, 2020

Authors:

Shengpan Chen

Jianhua Peng

Prativa Sherchan

Abstract

BACKGROUND: Neuroinflammation is an important host defense response to secondary brain injury after intracerebral hemorrhage (ICH). Triggering receptor expressed on myeloid cells 2 (TREM2) confers strong neuroprotective effects by attenuating neuroinflammation in experimental ischemic stroke. Recent...

Subject

Neuroinflammation

PI3K/AKT/mTOR pathway

Intracerebral hemorrhage

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