Single-cell transcriptomic architecture and intercellular crosstalk of human intrahepatic cholangiocarcinoma

Zhang, Min; Yang, Hui; Wan, Lingfei; Wang, Zhao-Hai; Wang, Haiyang; Chen, Ge; Liu, Yunhui; Hao, Yajing; Zhang, Dongdong; Shi, Gaona; Gong, Yandong; Ni, Yanli; Wang, Chaojie; Zhang, Yuan; Xi, Jiafei; Wang, Sen; Shi, Lei; Zhang, Lina; Yue, Wen; Pei, Xuetao; Liu, Bing; Yan, Xinlong

doi:10.1016/j.jhep.2020.05.039

Public

Single-cell transcriptomic architecture and intercellular crosstalk of human intrahepatic cholangiocarcinoma

Published in Journal of Hepatology • Jun 5, 2020

Authors:

Min Zhang

Hui Yang

Lingfei Wan

Abstract

•Single cell transcriptomic datasets are a valuable resource to dissect cellular diversity and intercellular crosstalk of human ICCs.•Malignant cells displayed remarkable inter-tumor heterogeneity and Tregs revealed highly immunosuppressive characteristics.•Six distinct fibroblast subsets were defin...

Subject

Biology

Stromal cell

Cancer-Associated Fibroblasts

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!