Single-cell transcriptomic architecture and intercellular crosstalk of human intrahepatic cholangiocarcinoma

Zhang, Min; Yang, Hui; Wan, Lingfei; Wang, Zhao-Hai; Wang, Haiyang; Chen, Ge; Liu, Yunhui; Hao, Yajing; Zhang, Dongdong; Shi, Gaona; Gong, Yandong; Ni, Yanli; Wang, Chaojie; Zhang, Yuan; Xi, Jiafei; Wang, Sen; Shi, Lei; Zhang, Lina; Yue, Wen; Pei, Xuetao; Liu, Bing; Yan, Xinlong

doi:10.1016/j.jhep.2020.05.039

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Single-cell transcriptomic architecture and intercellular crosstalk of human intrahepatic cholangiocarcinoma

Published in Journal of Hepatology • Jun 5, 2020

Authors:

Min Zhang

Hui Yang

Lingfei Wan

Abstract

BACKGROUND & AIMS: Intrahepatic cholangiocarcinoma (ICC) is the second most common liver malignancy. ICC typically features remarkable cellular heterogeneity and a dense stromal reaction. Therefore, a comprehensive understanding of cellular diversity and the interplay between malignant cells and nic...

Subject

Biology

Stromal cell

Cancer-Associated Fibroblasts

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