Development of CRISPR-Cas13a-based antimicrobials capable of sequence-specific killing of target bacteria

Kiga, Kotaro; Tan, Xin-Ee; Ibarra‐Chávez, Rodrigo; Watanabe, Shinya; Aiba, Yoshifumi; Sato’o, Yusuke; Li, Feng-Yu; Sasahara, Teppei; Cui, Bintao; Kawauchi, Moriyuki; Boonsiri, Tanit; Thitiananpakorn, Kanate; Taki, Yusuke; Haeruman Azam, Aa; Suzuki, Masato; R. Penadés, José; Cui, Longzhu

doi:10.1038/s41467-020-16731-6

Public

Development of CRISPR-Cas13a-based antimicrobials capable of sequence-specific killing of target bacteria

Published in Nature Communications • Jun 10, 2020

Authors:

Kotaro Kiga

Xin-Ee Tan

Rodrigo Ibarra‐Chávez

Abstract

The emergence of antimicrobial-resistant bacteria is an increasingly serious threat to global health, necessitating the development of innovative antimicrobials. Here we report the development of a series of CRISPR-Cas13a-based antibacterial nucleocapsids, termed CapsidCas13a(s), capable of sequence...

Subject

CRISPR

Antimicrobial

Bacteria

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