The novel dual glucose‐dependent insulinotropic polypeptide and glucagon‐like peptide‐1 ( <scp>GLP</scp> ‐1) receptor agonist tirzepatide transiently delays gastric emptying similarly to selective <scp>long‐acting GLP</scp> ‐1 receptor agonists

Urva, Shweta; Coşkun, Tamer; Loghin, Corina; Cui, Xuewei; Beebe, Emily; S. O’Farrell, Libbey; A. Briere, Daniel; Benson, Charles; A. Nauck, Michael; Haupt, Axel

doi:10.1111/dom.14110

Public

The novel dual glucose‐dependent insulinotropic polypeptide and glucagon‐like peptide‐1 ( GLP ‐1) receptor agonist tirzepatide transiently delays gastric emptying similarly to selective long‐acting GLP ‐1 receptor agonists

Published in Diabetes Obesity and Metabolism • Jun 10, 2020

Authors:

Shweta Urva

Tamer Coşkun

Corina Loghin

Abstract

The effect of dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist (RA) tirzepatide on gastric emptying (GE) was compared to that of GLP-1RAs in non-clinical and clinical studies. GE was assessed following acute and chronic treatment with tirze...

Subject

Semaglutide

Medicine

Dulaglutide

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