Rationale for Timely Insulin Therapy in Type 2 Diabetes Within the Framework of Individualised Treatment: 2020 Update

Hanefeld, M; Fleischmann, Holger; Siegmund, Thorsten; Seufert, Jochen

doi:10.1007/s13300-020-00855-5

Public

Rationale for Timely Insulin Therapy in Type 2 Diabetes Within the Framework of Individualised Treatment: 2020 Update

Published in Diabetes Therapy • Jun 20, 2020

Authors:

M Hanefeld

Holger Fleischmann

Thorsten Siegmund

Abstract

Type 2 diabetes is characterised by chronic hyperglycaemia and variable degrees of insulin deficiency and resistance. Hyperglycaemia and elevated fatty acids exert harmful effects on β-cell function, regeneration and apoptosis (gluco-lipotoxicity). Furthermore, chronic hyperglycaemia triggers a vici...

Subject

Medicine

Insulin resistance

Lipotoxicity

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