Clinical-Grade Detection of Microsatellite Instability in Colorectal Tumors by Deep Learning

Echle, Amelie; I. Grabsch, Heike; Quirke, Philip; A. van den Brandt, Piet; P. West, Nicholas; Hutchins, Gordon; R. Heij, Lara; Tan, Xiuxiang; D. Richman, Susan; Krause, Jeremias; Alwers, Elizabeth; C.A. Jenniskens, Josien; Offermans, Kelly; Gray, Richard; Brenner, Hermann; Chang‐Claude, Jenny; Trautwein, Christian; T. Pearson, Alexander; Boor, Peter; Luedde, Tom; T. Gaisa, Nadine; Hoffmeister, Michael; Nikolas Kather, Jakob

doi:10.1053/j.gastro.2020.06.021

Public

Clinical-Grade Detection of Microsatellite Instability in Colorectal Tumors by Deep Learning

Published in Gastroenterology • Jun 17, 2020

Authors:

Amelie Echle

Heike I. Grabsch

Philip Quirke

Abstract

BACKGROUND & AIMS: Microsatellite instability (MSI) and mismatch-repair deficiency (dMMR) in colorectal tumors are used to select treatment for patients. Deep learning can detect MSI and dMMR in tumor samples on routine histology slides faster and less expensively than molecular assays. However, cli...

Subject

Microsatellite instability

Colorectal cancer

Instability

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