Immunoglobulin light-chain toxicity in a mouse model of monoclonal immunoglobulin light-chain deposition disease.

S, Bender; MV, Ayala; A, Bonaud; V, Javaugue; C, Carrion; C, Oblet; A, Rinsant; S, Kaaki; Z, Oruc; F, Boyer; A, Paquet; N, Pons; B, Hervé; MO, Ashi; A, Jaccard; L, Delpy; G, Touchard; M, Cogné; F, Bridoux; C, Sirac

doi:10.1182/blood.2020005980

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Immunoglobulin light-chain toxicity in a mouse model of monoclonal immunoglobulin light-chain deposition disease.

Shared by NobleBlocks on Oct 1, 2020 • 12:00 AM UTC

Authors:

Bender S

Ayala MV

Bonaud A

Abstract

Light chain (LC) deposition disease (LCDD) is a rare disorder characterized by glomerular and peritubular amorphous deposits of a monoclonal immunoglobulin LC, leading to nodular glomerulosclerosis and nephrotic syndrome. We developed a transgenic model using site-directed insertion of the variable ...

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