The serine hydroxymethyltransferase-2 (SHMT2) initiates lymphoma development through epigenetic tumor suppressor silencing.

S, Parsa; A, Ortega-Molina; HY, Ying; M, Jiang; M, Teater; J, Wang; C, Zhao; E, Reznik; JP, Pasion; D, Kuo; P, Mohan; S, Wang; JM, Camarillo; PM, Thomas; N, Jain; J, Garcia-Bermudez; BK, Cho; W, Tam; NL, Kelleher; N, Socci; A, Dogan; Stanchina E, De; G, Ciriello; MR, Green; S, Li; K, Birsoy; AM, Melnick; HG, Wendel

doi:10.1038/s43018-020-0080-0

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The serine hydroxymethyltransferase-2 (SHMT2) initiates lymphoma development through epigenetic tumor suppressor silencing.

Shared by NobleBlocks on Jun 22, 2020 • 12:00 AM UTC

Authors:

Parsa S

Ortega-Molina A

Ying HY

Abstract

Cancer cells adapt their metabolic activities to support growth and proliferation. However, increased activity of metabolic enzymes is not usually considered an initiating event in the malignant process. Here, we investigate the possible role of the enzyme serine hydroxymethyltransferase-2 (SHMT2) i...

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