A neutralizing human antibody binds to the N-terminal domain of the Spike protein of SARS-CoV-2

Chi, Xiangyang; Yan, Renhong; Zhang, Jun; Zhang, Jun; Zhang, Guanying; Zhang, Yuanyuan; Hao, Meng; Zhang, Zhe; Fan, Pengfei; Dong, Yunzhu; Yang, Yilong; Chen, Zhengshan; Guo, Yingying; Zhang, Jinlong; Zhang, Jinlong; Li, Yaning; Song, Xiaohong; Chen, Yi; Xia, Lu; Fu, Ling; Hou, Lihua; Xu, Junjie; Yu, Changming; Li, Jianmin; Zhou, Qiang; Chen, Wei

doi:10.1126/science.abc6952

Public

A neutralizing human antibody binds to the N-terminal domain of the Spike protein of SARS-CoV-2

Published in Science • Jun 22, 2020

Authors:

Xiangyang Chi

Renhong Yan

Jun Zhang

Abstract

Developing therapeutics against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) could be guided by the distribution of epitopes, not only on the receptor binding domain (RBD) of the Spike (S) protein but also across the full Spike (S) protein. We isolated and characterized monoclonal an...

Subject

Spike Protein

Spike (software development)

Terminal (telecommunication)

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