Structures of Human Antibodies Bound to SARS-CoV-2 Spike Reveal Common Epitopes and Recurrent Features of Antibodies

O. Barnes, Christopher; P. West, Anthony; E. Huey‐Tubman, Kathryn; A. G. Hoffmann, Magnus; G. Sharaf, Naima; R. Hoffman, Pauline; Koranda, Nicholas; B. Gristick, Harry; Gaebler, Christian; Muecksch, Frauke; C. C. Lorenzi, Julio; Finkin, Shlomo; Hägglöf, Thomas; Hurley, Arlene; G. Millard, Katrina; Weisblum, Yiska; Schmidt, Fabian; Hatziioannou, Théodora; D. Bieniasz, Paul; Caskey, Marina; F. Robbiani, Davide; C. Nussenzweig, Michel; J. Björkman, Pamela

doi:10.1016/j.cell.2020.06.025

Public

Structures of Human Antibodies Bound to SARS-CoV-2 Spike Reveal Common Epitopes and Recurrent Features of Antibodies

Published in Cell • Jun 24, 2020

Authors:

Christopher O. Barnes

Anthony P. West

Kathryn E. Huey‐Tubman

Abstract

and RBD epitopes on SARS-CoV-2 spike. Moreover, a 3.4 Å cryo-electron microscopy (cryo-EM) structure of a neutralizing monoclonal Fab-spike complex revealed an epitope that blocks ACE2 receptor binding. Modeling based on these structures suggested different potentials for inter-spike crosslinking by...

Subject

Epitope

Polyclonal antibodies

Avidity

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