MICOS assembly controls mitochondrial inner membrane remodeling and crista junction redistribution to mediate cristae formation

Stephan, Till; Brüser, Christian; Deckers, Markus; M. Steyer, Anna; Balzarotti, Francisco; Barbot, Mariam; S Behr, Tiana; Heim, Gudrun; Hübner, Wolfgang; Ilgen, Peter; de Lange, F.; Pacheu‐Grau, David; K. Pape, Jasmin; Stoldt, Stefan; Huser, Thomas; W. Hell, Stefan; Möbius, Wiebke; Rehling, Peter; Riedel, Dietmar; Jakobs, Stefan

doi:10.15252/embj.2019104105

Public

MICOS assembly controls mitochondrial inner membrane remodeling and crista junction redistribution to mediate cristae formation

Published in The EMBO Journal • Jun 22, 2020

Authors:

Till Stephan

Christian Brüser

Markus Deckers

Abstract

Abstract Mitochondrial function is critically dependent on the folding of the mitochondrial inner membrane into cristae; indeed, numerous human diseases are associated with aberrant crista morphologies. With the MICOS complex, OPA1 and the F 1 F o ‐ATP synthase, key players of cristae biogenesis hav...

Subject

Crista

Biology

Inner membrane

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