Pickering emulsions with ethiodized oil and nanoparticles for slow release of intratumoral anti-CTLA4 immune checkpoint antibodies

Tselikas, Lambros; de Baère, Thierry; Isoardo, Thomas; Susini, Sandrine; Ser‐Le Roux, Karine; Polrot, Mélanie; Adam, Julien; Rouanne, Mathieu; Zitvogel, Laurence; Moine, Laurence; Deschamps, Frédèric; Marabelle, Aurélien

doi:10.1136/jitc-2020-000579

Public

Pickering emulsions with ethiodized oil and nanoparticles for slow release of intratumoral anti-CTLA4 immune checkpoint antibodies

Published in Journal for ImmunoTherapy of Cancer • Jun 1, 2020

Authors:

Lambros Tselikas

Thierry de Baère

Thomas Isoardo

Abstract

BACKGROUND: Intratumorous immunotherapy for cancer is currently thriving. The aim of such local strategy is to improve the therapeutic index of these treatments, for higher on-target/on-tumor activity and less on-target/off-tumor adverse events. Strategies allowing for slow release of anti-CTLA4 in ...

Subject

PLGA

Pickering emulsion

Antibody

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