Breast cancer colonization by Fusobacterium nucleatum accelerates tumor growth and metastatic progression

Parhi, Lishay; Alon‐Maimon, Tamar; Sol, Asaf; Nejman, Deborah; Shhadeh, Amjad; Fainsod-Levi, Tanya; Yajuk, Olga; Isaacson, Batya; Abed, Jawad; Maalouf, Naseem; Nissan, Aviram; Sandbank, Judith; Yehuda‐Shnaidman, Einav; Ponath, Falk; Vogel, Jörg; Mandelboim, Ofer; Granot, Zvi; Straussman, Ravid; Bachrach, Gilad

doi:10.1038/s41467-020-16967-2

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Breast cancer colonization by Fusobacterium nucleatum accelerates tumor growth and metastatic progression

Published in Nature Communications • Jun 26, 2020

Authors:

Lishay Parhi

Tamar Alon‐Maimon

Asaf Sol

Abstract

Fusobacterium nucleatum is an oral anaerobe recently found to be prevalent in human colorectal cancer (CRC) where it is associated with poor treatment outcome. In mice, hematogenous F. nucleatum can colonize CRC tissue using its lectin Fap2, which attaches to tumor-displayed Gal-GalNAc. Here, we sho...

Subject

Fusobacterium nucleatum

Colonization

Colorectal cancer

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