Mitochondria transfer enhances proliferation, migration, and osteogenic differentiation of bone marrow mesenchymal stem cell and promotes bone defect healing

Guo, Yusi; Chi, Xiaopei; Wang, Yifan; Chin Heng, Boon; Wei, Yan; Zhang, Xuehui; Zhao, Han; Yin, Ying; Deng, Xuliang

doi:10.1186/s13287-020-01704-9

Public

Mitochondria transfer enhances proliferation, migration, and osteogenic differentiation of bone marrow mesenchymal stem cell and promotes bone defect healing

Published in Stem Cell Research & Therapy • Jun 25, 2020

Authors:

Yusi Guo

Xiaopei Chi

Yifan Wang

Abstract

BACKGROUND: Bone marrow-derived mesenchymal stem cell (BMSC) transplantation is considered a promising therapeutic approach for bone defect repair. However, during the transplantation procedure, the functions and viability of BMSCs may be impaired due to extended durations of in vitro culture, aging...

Subject

Mesenchymal stem cell

Transplantation

Cell biology

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