Tumor invasion in draining lymph nodes is associated with Treg accumulation in breast cancer patients

Gonzalo Núñez, Nicolas; Tosello Boari, Jimena; Nalio Ramos, Rodrigo; Richer, Wilfrid; Cagnard, Nicolas; Dimitri Anderfuhren, Cyrill; Laura Niborski, Leticia; Bigot, Jeremy; Meseure, Didier; De La Rochere, Philippe; Milder, Maud; Viel, Sophie; Loirat, Delphine; Pérol, Louis; Vincent-Salomon, Anne; Sastre-Garau, Xavier; Burkhard, Becher; Sedlik, Christine; Lantz, Olivier; Amigorena, Sebastian; Piaggio, Eliane

doi:10.1038/s41467-020-17046-2

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Tumor invasion in draining lymph nodes is associated with Treg accumulation in breast cancer patients

Shared by NobleBlocks on Jun 28, 2020 • 12:00 AM UTC

Authors:

Nicolas Gonzalo Núñez

Jimena Tosello Boari

Rodrigo Nalio Ramos

Abstract

Abstract Tumor-draining lymph node (TDLN) invasion by metastatic cells in breast cancer correlates with poor prognosis and is associated with local immunosuppression, which can be partly mediated by regulatory T cells (Tregs). Here, we study Tregs from matched tumor-invaded and non-invaded TDLNs, an...

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