FAPI-74 PET/CT Using Either <sup>18</sup>F-AlF or Cold-Kit <sup>68</sup>Ga Labeling: Biodistribution, Radiation Dosimetry, and Tumor Delineation in Lung Cancer Patients.

FL, Giesel; S, Adeberg; M, Syed; T, Lindner; LD, Jiménez-Franco; E, Mavriopoulou; F, Staudinger; E, Tonndorf-Martini; S, Regnery; S, Rieken; Shafie R, El; M, Röhrich; P, Flechsig; A, Kluge; A, Altmann; J, Debus; U, Haberkorn; C, Kratochwil

doi:10.2967/jnumed.120.245084

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FAPI-74 PET/CT Using Either 18F-AlF or Cold-Kit 68Ga Labeling: Biodistribution, Radiation Dosimetry, and Tumor Delineation in Lung Cancer Patients.

Shared by NobleBlocks on Jun 26, 2020 • 12:00 AM UTC

Authors:

Giesel FL

Adeberg S

Syed M

Abstract

68Ga-fibroblast activation protein inhibitors (FAPIs) 2, 4, and 46 have already been proposed as promising PET tracers. However, the short half-life of 68Ga (68 min) creates problems with manufacture and delivery. 18F (half-life, 110 min) labeling would result in a more practical large-scale product...

Subject

Lung cancer

Radiation Dosimetry

Cancer-associated Fibroblasts

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